Sildenafil (Viagra®) prevents and restores LPS-induced inflammation in astrocytes
نویسندگان
چکیده
منابع مشابه
Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats
Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...
متن کاملAlliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes
Garlic (Allium sativum L.) has been used to alleviate a variety of health problems due to its high content of organosulfur compounds and antioxidant activity. The main active component is alliin (S-allyl cysteine sulfoxide), a potent antioxidant with cardioprotective and neuroprotective actions. In addition, it helps to decrease serum levels of glucose, insulin, triglycerides, and uric acid, as...
متن کاملMeasurement of choroidal perfusion and thickness following systemic sildenafil (Viagra(®) ).
PURPOSE To demonstrate anatomic and physiologic changes in the human choroid following systemic sildenafil citrate (Viagra®) using enhanced depth imaging spectral domain-optical coherence tomography (EDI-OCT) and swept-scan high-frequency digital ultrasound. METHODS Seven healthy male subjects (mean age 32.7 years) were evaluated at baseline and 2 hr after ingesting 50 mg of sildenafil. Swept...
متن کاملMacelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats.
Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of th...
متن کاملSildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke
Ruilan Zhang, Ying Wang, Li Zhang, Zhenggang Zhang, Wayne Tsang, Mei Lu, Lijie Zhang in Rats Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi:...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2016
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2016.07.029